DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR>30 mL/min
HD                     :Not dialysed. Dose as in GFR>30 mL/min
HDF/high flux   :Dialysed. Dose as in GFR>30 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in GFR>30 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
None known
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
13.5% of dose is removed during a 3–4 hour haemodialysis sessionIn severe renal impairment (GFR<30 mL/min) the AUC was increased 4-fold50 mg and 25 mg tablets are only available in the USA at present.