senna – kdc

CLINICAL USE

Constipation

DOSE IN NORMAL RENAL FUNCTION

Tablets: 15–30 mg (2–4 tablets) at nightGranules: 5–10 mL at nightSyrup:

10 to 20 : mL at nightManevac granules: 5–10 mL every 6–12 hours

PHARMACOKINETICS

Molecular weight :862.7

%Protein binding :Systemic bioavailability less than 5%

%Excreted unchanged in urine : No data

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :No data

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Acts in 8–12 hours Syrup available, 5 mL ≡ 1 tabletGranules available, 1 × 5 mL spoonful ≡ 2 tabletsDiabetic patients should use the tablets as these have negligible sugar content.

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