Volume of distribution (L/kg)       :Depends on body weight (higher in obese patients)
half-life – normal/ESRD (hrs)      :9 days (16 days in obese patients)
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function. Use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min
HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsKetoconazole: concentration of rimonabant increased
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Manufacturer states use contraindicated in CKD 5 due to lack of dataDo not use in patients with major depression or who are on an antidepressant as there is a high risk of depression reported with rimonabant.