CLINICAL USE
Antibacterial agent:Tuberculosis Staphylococcal infection
DOSE IN NORMAL RENAL FUNCTION
600–1200 mg daily in 2–4 divided dosesPHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsADMINISTRATION
Reconstition
Use solvent providedRoute
Oral, IVRate of Administration
2–3 hoursComments
Dilute in 500 mL glucose 5% or sodium chloride 0.9%For central administration, 600 mg in 100 mL glucose 5% over 0.5–2 hours has been used (unlicensed). Stable for up to 24 hours at room temperatureOTHER INFORMATION
Some units give dose in concentrations up to 60 mg/mL (in its own solvent) over 10 minutes, on prescriber’s responsibilityMay cause acute interstitial nephritis, potassium wasting or renal tubular defectsReduce dose if LFTs are abnormal or patient <45 kgAbsorption from gastrointestinal tract can be reduced by up to 80% by the presence of food in the gastrointestinal tractCAPD exit site infections: 300 mg twice daily for 4 weeks has been usedRifampicin is excreted into
CAPD fluid causing an orange/yellow colourMonitor rifampicin levels if necessary In severe renal impairment there is no increase in half-life at doses less than 600 mg daily.