reboxetine.txt CLINICAL USE Antidepressant DOSE IN NORMAL RENAL FUNCTION 4–5 mg twice daily; maximum 12 mg daily PHARMACOKINETICS Molecular weight                           :409.5 (as mesilate) %Protein binding                           :97 (92% in elderly) %Excreted unchanged in urine     : 10 Volume of distribution (L/kg)       :26–63 litres half-life – normal/ESRD (hrs)      :13/26 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : 2 mg twice daily and adjust according to response <10           : 2 mg twice daily and adjust according to response DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min HD                     :Unknown dialysability. Dose as in GFR <10 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antibacterials: avoid concomitant use with macrolides and linezolid Antidepressants: risk of increased toxicity with concomitant use with MAOI’s; avoid concomitant use with fluvoxamine Antifungals: avoid concomitant use with imidazoles and triazoles Antimalarials: avoid concomitant use with artemether with lumefantrine Ciclosporin: use with caution as high concentrations of reboxetine inhibit CYP3A4 and CYP2D6 Sibutramine: increased risk of CNS toxicity – avoid concomitant use ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments–. Tags: post-by-auto-php Continue Reading Previous Previous post: primidone.txtNext Next post: risedronate sodium.txt Related News sotalol hydrochloride.txt tazocin.txt