20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in normal renal function
HD                     :Unlikely to be dialysed. Dose as in normal renal function
HDF/high flux   :Unknown dialysability. Dose as in normal renal function
CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Anticoagulants: antagonism of anticoagulant effect of coumarinsColestyramine: reduced absorption of raloxifene – avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
There are case reports of it being beneficial in females on haemodialysis and also a benefit to the lipid profile. (Hernandez E, Valera R, Alonzo E, et al. Effects of raloxifene on bone metabolism and serum lipids in post-menopausal women on chronic haemodialysis. Kidney Int. 2003; 63(6): 2269–74.)This study showed that raloxifene could reduce vertebral fractures although they were more likely to suffer from side effects. (Ishani A, Blackwell T, Jamal SA, et al. The effect of raloxifene treatment in post-menopausal women with CKD. J Am Soc Nephrol. 2008; 19:1430–8.)Manufacturer advises use is contraindicated in severe renal impairment due to lack of data rather than known toxicity< 6% of dose is excreted in the urine