CLINICAL USE

Vitamin B6

DOSE IN NORMAL RENAL FUNCTION

Deficiency:

  • 20 to 50     : mg up to 3 times daily Prophylaxis against isoniazid neuropathy:
  • 10 to 20     : mg daily; 50 mg 3 times daily for treatmentIdiopathic sideroblastic anaemia: 100– 400 mg daily in divided dosesPremenstrual syndrome: 50–100 mg daily

    PHARMACOKINETICS

  • Molecular weight                           :205.6
  • %Protein binding                           :High (as pyridoxal and pyridoxal phosphate)
  • %Excreted unchanged in urine     : No data
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :15–20 days

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Dialysed. Dose as in normal renal function
  • HDF/high flux   :Dialysed. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Long-term use of pyridoxine in doses greater than 200 mg daily has been associated with neuropathy

    • Tags:

    Related News

    ffddfd

    Hyperlipidemia