pyrazinamide.txt CLINICAL USE Antimicrobial agent for tuberculosis DOSE IN NORMAL RENAL FUNCTION 1.5–2 g per day PHARMACOKINETICS Molecular weight                           :123.1 %Protein binding                           :10 %Excreted unchanged in urine     : 4 Volume of distribution (L/kg)       :0.75–1.3 half-life – normal/ESRD (hrs)      :9–10/26 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Use 50–100% of dose DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :50–100% dialysed. Dose as in GFR <10 mL/min or 25–30 mg/kg post dialysis1HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/min or 25–30 mg/kg post dialysis1CAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Ciclosporin: on limited evidence, pyrazinamide appears to reduce ciclosporin levels ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– OTHER INFORMATION Available from IDIS on a named patient basis. Can precipitate gout as impairs urate excretion Tags: post-by-auto-php Continue Reading Previous Previous post: primidone.txtNext Next post: risedronate sodium.txt Related News sotalol hydrochloride.txt tazocin.txt