pyrazinamide

CLINICAL USE

Antimicrobial agent for tuberculosis

DOSE IN NORMAL RENAL FUNCTION

1.5–2 g per day

PHARMACOKINETICS

Molecular weight :123.1

%Protein binding :10

%Excreted unchanged in urine : 4

Volume of distribution (L/kg) :0.75–1.3

half-life – normal/ESRD (hrs) :9–10/26

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Use 50–100% of dose

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :50–100% dialysed. Dose as in GFR <10 mL/min or 25–30 mg/kg post dialysis1

HDF/high flux :Dialysed. Dose as in GFR

<10 : mL/min or 25–30 mg/kg post dialysis1

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Ciclosporin: on limited evidence, pyrazinamide appears to reduce ciclosporin levels

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Available from IDIS on a named patient basis. Can precipitate gout as impairs urate excretion

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