20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in normal renal function
HD                     :Unknown dialysability. Dose as in normal renal function
HDF/high flux   :Unknown dialysability. Dose as in normal renal function
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
None known
ADMINISTRATION
Reconstition
–
Route
–
Rate of Administration
5 mg/minute
Comments
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OTHER INFORMATION
Counteracting the anticoagulant effect of heparin during extra-corporeal treatments requires approximately 1.5 mg protamine per 100 IU heparinMost clinicians recommend a dose of 1–1.5 mg protamine sulphate for each 100 units heparin given depending on the length of time since heparin administrationMay be used topically to stop bleeding fistulae