Propylthiouracil.txt

CLINICAL USE

Hyperthyroidism

DOSE IN NORMAL RENAL FUNCTION

Initially: 200–400 mg dailyMaintenance dose: 50–150 mg daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :170.2

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :80

%Excreted unchanged in urine &nbsp &nbsp : <2

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :0.3–0.4

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :1–2/8.5

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : 75% of normal dose and titrate to response

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50% of normal dose and titrate to response

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Renally impaired patients are at a greater risk of cardiotoxicity and leucopenia.

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