CLINICAL USE

Antihistamine

DOSE IN NORMAL RENAL FUNCTION

Oral: 25 mg at night increased to twice daily, or

  • 10 to 20     : mg 2–3 times a daySlow IV/IM: 25–100 mg

    PHARMACOKINETICS

  • Molecular weight                           :320.9
  • %Protein binding                           :76–93
  • %Excreted unchanged in urine     : 0
  • Volume of distribution (L/kg)       :13.5
  • half-life – normal/ESRD (hrs)      :5–14/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    IV, IM, oral

    Rate of Administration

    Bolus over 3–5 minutes

    Comments

    Administer in 10 mL water for injection for slow IV injection (2.5 mg/mL)

    OTHER INFORMATION

    Excessive sedation may occur in CKD 5

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