Piperazine

CLINICAL USE

Treatment of threadworm and roundworm infections

DOSE IN NORMAL RENAL FUNCTION

Threadworm: 4 g sachet stirred into a glass of milk or water and drunk immediately; repeat after 14 daysRoundworms: 4 g sachet stirred into a glass of milk or water and drunk immediately; repeat at monthly intervals for up to 3 months if re-infection risk

PHARMACOKINETICS

Molecular weight :86.14 (202.1 as phosphate); (642.7 as citrate)

%Protein binding :No data

%Excreted unchanged in urine : 5–30

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :No data

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function but avoid repeated administration

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in GFR <10 mL/min

HD :Unknown dialysability. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsPyrantel: antagonises effect of piperazine

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

May accumulate in severe renal impairment causing neurotoxicityActs within the lumen of the gastrointestinal tract which is independent of any systemic absorption.

Tags: post-by-auto-php