phentolamine mesilate

CLINICAL USE

Alpha-adrenoceptor blocker:Hypertensive crisis

DOSE IN NORMAL RENAL FUNCTION

2–5 mg repeated if necessary

PHARMACOKINETICS

Molecular weight :377.5

%Protein binding :54

%Excreted unchanged in urine : 13

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :19 minutes/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function Titrate dose to end point, i.e. lower BP

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Antidepressants: additive hypotensive effect with MAOIs – avoid concomitant useAntihypertensives: enhanced hypotensive effect

Diuretics: enhanced hypotensive effect Linezolid: additive hypotensive effect

Moxisylyte: possibly severe postural hypotension

Vardenafil, sildenafil and tadalafil: enhanced hypotensive effect – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Rate of Administration

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Comments

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OTHER INFORMATION

Titrate according to response

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