CLINICAL USE


Peripheral vascular disease Venous leg ulcers (unlicensed indication)

DOSE IN NORMAL RENAL FUNCTION

400 mg 2 to 3 times daily

PHARMACOKINETICS

  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :278.3
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0
  • %Excreted unchanged in urine &nbsp &nbsp : 0 (95% as active metabolites)
  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp :2.4–4.2
  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :0.4–1/Unchanged (see ‘Other Information’)

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

    30–50 Dose as in normal renal function10–30 Reduce dose by 30–50% depending on individual tolerance (400 mg once or twice daily)
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Reduce dose by 30–50% depending on individual tolerance (400 mg once or twice daily)

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. 400 mg daily, slowly increasing if necessary

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. 400 mg daily, slowly increasing if necessary
  • HDF/high flux &nbsp :Unknown dialysability. 400 mg daily, slowly increasing if necessary
  • CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR=10–30 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Analgesics: possibly increased risk of bleeding when administered in combination with NSAIDs; increased risk of bleeding with ketorolac – avoid concomitant use

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

    May enhance hypoglycaemia Avoid in porphyria Active metabolites are renally excreted and have an extended half-life in renal impairment