CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

500–1000 mg every 6 hours

PHARMACOKINETICS

  • Molecular weight                           :350.4
  • %Protein binding                           :80
  • %Excreted unchanged in urine     : 60–90
  • Volume of distribution (L/kg)       :0.5
  • half-life – normal/ESRD (hrs)      :0.5–1/4

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as normal renal function
  • HD                     :Dialysed. Dose as in normal renal function
  • HDF/high flux   :Dialysed. Dose as in normal renal function
  • CAV/VVHD      :Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsReduces excretion of methotrexate

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Renal failure prolongs half-life of phenoxymethylpenicillin, but as it has a wide therapeutic index no dose adjustment is necessary

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