20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Start with small doses.
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
HDF/high flux   :Dialysed. Dose as in GFR
<10           : mL/min
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Anti-arrhythmics: delayed absorption of mexiletine
Antidepressants: CNS excitation or depression with MAOIs – avoid concomitant use; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics
Antivirals: concentration possibly increased by ritonavirSodium oxybate: enhanced effect of sodium oxybate – avoid concomitant use
ADMINISTRATION
Reconstition
–
Route
Oral, IV, IM, SC
Rate of Administration
Infusion over 24 hours
Comments
Dilute to a concentration of 1 mg/mL with glucose 5% or sodium chloride 0.9%
OTHER INFORMATION
Has been used in CKD 5 patients; start with lowest dose and gradually increase dose according to responseLimited accumulation of metabolites in renal failure compared with morphineIncreased volume of distribution in renal failure(Kirvela M, Lindgren L, Seppala T, et al. The pharmacokinetics of oxycodone in uremic patients undergoing renal transplantation. Journal of Clinical Anaesthesia. 1996; 8: 13–18.)2 mg of oral oxycodone is approximately equivalent to 1 mg of parenteral oxycodone