oxprenolol hydrochloride.txt

CLINICAL USE

Beta-1 adrenoceptor blocker:Hypertension Angina Arrhythmias Anxiety

DOSE IN NORMAL RENAL FUNCTION

Hypertension, angina: 80–160 mg daily in 2–3 divided doses; maximum 320 mg dailyArrhythmias: 40–240 mg daily in 2–3 divided dosesAnxiety: 40–80 mg daily in 1–2 divided doses

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :301.8

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :70–80

%Excreted unchanged in urine &nbsp &nbsp : <3

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :1.2

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :1–2/unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely dialysability. Dose as in normal renal function.

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely dialysability. Dose as in normal renal function.

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Analgesics: NSAIDs antagonise hypotensive effect

Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone

Antidepressants: enhanced hypotensive effect with MAOIsAntihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin; increased risk of withdrawal hypertension with clonidine; increased risk of bradycardia and AV block with diltiazem; severe hypotension and heart failure occasionally with nifedipine; asystole, severe hypotension and heart failure with verapamil

Antimalarials: increased risk of bradycardia with mefloquine

Antipsychotics: enhanced hypotensive effect with phenothiazines

Diuretics: enhanced hypotensive effect

Moxisylyte: possibly severe postural hypotensionSevere hypertension with adrenaline and noradrenaline (especially with non-selective beta-blockers) and possibly with dopamineTropisetron: increased risk of ventricular arrhythmias – use with caution

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

Use with caution in patients with chronic obstructive airways disease, asthma or diabetesRhabdomyolysis with myoglobinuria has been reported in severe overdosage with oxprenolol

Tags: post-by-auto-php