CLINICAL USE
Anti-epileptic agent Trigeminal neuralgia (unlicensed indication)
DOSE IN NORMAL RENAL FUNCTION
Epilepsy: 600 mg–2.4 g daily in divided dosesTrigeminal neuralgia: 400–2.4 g in 2–4 divided dosesPHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–50 Dose as in normal renal function 10–30 Dose as in normal renal function. Start with 300 mg daily and titrate slowlyDOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsADMINISTRATION
Reconstition
–Route
OralRate of Administration
–Comments
–OTHER INFORMATION
Metabolised to active monohydroxy metaboliteHyponatraemia is more common with oxcarbazepine than carbamazepine, monitoring is recommendedMaximum plasma concentrations reached after about 1 hour.