ondansetron.txt CLINICAL USE Anti-emetic DOSE IN NORMAL RENAL FUNCTION Oral: 4–24 mg daily in 2–3 divided dosesIV: 8–32 mg dailyPR: 16 mg pre-chemotherapy PHARMACOKINETICS Molecular weight                           :293.4 %Protein binding                           :70–76 %Excreted unchanged in urine     : <5 Volume of distribution (L/kg)       :2 half-life – normal/ESRD (hrs)      :3–6/5.4 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unlikely to be dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal function CAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs None known ADMINISTRATION Reconstition– Route Oral, IV, IM, rectal Rate of Administration IV bolus over 3–5 minutes IV infusion : over 15 minutes Continuous infusion: 1 mg/hour CommentsDilute in 50–100 mL of sodium chloride 0.9% or glucose 5% OTHER INFORMATION Can be used to treat uraemic pruritus Renal clearance of ondansetron is low Tags: post-by-auto-php Continue Reading Previous Previous post: naproxen.txtNext Next post: orphenadrine hydrochloride.txt Related News sotalol hydrochloride.txt tazocin.txt