CLINICAL USE


Anti-emetic

DOSE IN NORMAL RENAL FUNCTION

Oral: 4–24 mg daily in 2–3 divided dosesIV: 8–32 mg dailyPR: 16 mg pre-chemotherapy

PHARMACOKINETICS

  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :293.4
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :70–76
  • %Excreted unchanged in urine &nbsp &nbsp : <5
  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp :2
  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :3–6/5.4

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • None known

    ADMINISTRATION

    Reconstition

    Route

    Oral, IV, IM, rectal

    Rate of Administration

    IV bolus over 3–5 minutes

    IV infusion

    : over 15 minutes Continuous infusion: 1 mg/hour

    Comments

    Dilute in 50–100 mL of sodium chloride 0.9% or glucose 5%

    OTHER INFORMATION

    Can be used to treat uraemic pruritus Renal clearance of ondansetron is low