ofloxacin.txt

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 200–400 mg daily, increased if necessary to 400 mg twice dailyIV: 200–400 mg twice daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :361.4

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :25

%Excreted unchanged in urine &nbsp &nbsp : 65–80

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :1.5–2.5

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :4–6/15–60

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : 200–400 mg once daily

10 to 20 &nbsp &nbsp : 200–400 mg once daily

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 200 mg once daily

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not significantly dialysed. Dose as in GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL/min

HDF/high flux &nbsp :Dialysed. Dose as in GFR

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL/min

CAV/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10–20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Analgesics: increased risk of convulsions with NSAIDs

Anticoagulants: effect of acenocoumarol and warfarin enhanced

Antimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant use

Ciclosporin: increased risk of nephrotoxicityTheophylline: possibly increased risk of convulsions

ADMINISTRATION

Reconstition

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Route

Oral, IV

Rate of Administration

200 mg over 30 minutes

Comments

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