CLINICAL USE
Relief of symptoms of gastroenteropancreatic endocrine tumours and acromegaly
DOSE IN NORMAL RENAL FUNCTION
50 micrograms – 1.2 mg daily
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
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Route
SC, IV
Rate of Administration
IV bolus with ECG monitoring
Comments
IV: sodium chloride 0.9% to a ratio of not less than 1:1 and not more than 1:9
OTHER INFORMATION
SC: to reduce local discomfort, warm to room temperature before injectionFor multiple injections, use different sites Patients with reduced renal function have been shown to have a reduced clearance of the drug (75 mL/minute vs. 175 mL/minute).