norfloxacin.txt

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

400 mg twice daily, duration of course depends on indication

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :319.3

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :14

%Excreted unchanged in urine &nbsp &nbsp : 30

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :2.5–3.1

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :3–4/6.5–8

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

30–50 Dose as in normal renal function 10–30 400 mg every 12 to 24 hours

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 400 mg daily

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR=10–30 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Analgesics: increased risk of convulsions with NSAIDs

Anticoagulants: anticoagulant effect of coumarins enhanced

Antimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant use

Ciclosporin: increased risk of nephrotoxicityTheophylline: possibly increased risk of convulsion; increased levels of theophylline

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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