nizatidine.txt CLINICAL USE H2-receptor antagonist DOSE IN NORMAL RENAL FUNCTION Oral: 150–600 mg dailyIV: 300–480 mg daily PHARMACOKINETICS Molecular weight                           :331.5 %Protein binding                           :35 %Excreted unchanged in urine     : 60 Volume of distribution (L/kg)       :0.8–1.3 half-life – normal/ESRD (hrs)      :1–2/3.5–11 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : 150–300 mg daily <20 150 mg daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR<20 mL/min HD                     :Not dialysed. Dose as in GFR<20 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR<20 mL/minCAV/VVHD      :Unknown dialysability. Dose as in GFR<20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antifungals: absorption of itraconazole and ketoconazole reduced ADMINISTRATION Reconstition– Route Oral, IV Rate of Administration Continuous IV infusion : Dilute 300 mg in 150 mL. Rate 10 mg/hour. Bolus: Dilute 100 mg in 50 mL and give over 15 minutesCommentsCompatible with sodium chloride 0.9% or glucose 5%.To maintain gastric pH ≥4, a continuous infusion of 10 mg/hour is recommended OTHER INFORMATION The effect of haemodialysis is unproven. It is not expected to be efficient since nizatidine has a large volume of distribution. Tags: post-by-auto-php Continue Reading Previous Previous post: naproxen.txtNext Next post: orphenadrine hydrochloride.txt Related News sotalol hydrochloride.txt tazocin.txt