Volume of distribution (L/kg)       :No data
half-life – normal/ESRD (hrs)      :4
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function. See ‘Other Information’
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antidepressants: avoid MAOIs; tricyclics possibly increased risk of side effects
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
–
OTHER INFORMATION
Avoid repeated or chronic administration in end stage renal disease and dialysis patientsIn the elderly a dose of 30 mg 8 hourly is recommended due to reduced metabolism and increased susceptibility to side effects. Renal patients may also have reduced metabolism and excretion so may also have the same problems – always start with the lower doseActive metabolites excreted in the urine .
