20 to 50     : Maximum 2.5 mg daily15–20 Maximum 2.5 mg daily<15 Use with caution – maximum 2.5 mg daily
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Likely dialysability. Dose as for GFR<15 mL/min
HD                     :Likely dialysability. Dose as for GFR<15 mL/min
HDF/high flux   :Likely dialysability. Dose as for GFR<15 mL/min
CAV/VVHD      :Unknown dialysability. Dose as for GFR=15–20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antidepressants: possibly increased serotonergic effects with duloxetine; increased serotonergic effects with St John’s wort – avoid concomitant use
Ergot alkaloids: increased risk of vasospasm – avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
Do not take second dose at 4 hours during an attack if the first dose was ineffectualNaratriptan is excreted by glomerular filtration and active secretion into the renal tubulesInactive metabolites are renally excreted Studies in patients with impaired renal function (GFR=18–115 mL/min) showed an 80% increase in half-life and a 50% decrease in clearance compared with matched individuals with normal renal function.