naloxone hydrochloride.txt

CLINICAL USE

Reversal of opioid induced respiratory depression

DOSE IN NORMAL RENAL FUNCTION

See ‘Other Information’

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :363.8

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :54

%Excreted unchanged in urine &nbsp &nbsp : 0

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :3

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :1–1.5/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

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Route

IV, IM, SC. IV more rapid response

Rate of Administration

Rapid if bolus injection

Comments

–

OTHER INFORMATION

IV postoperative use: Give 1.5–3 micrograms/kg; if response inadequate, increments of 100 micrograms every 2 minutes. Further dose by IM injection if neededOR dilute 400 micrograms in 100 mL sodium chloride 0.9% or glucose 5% (4 micrograms/mL) and give by continuous infusion. Titrate dose according to responseOpioid overdosage: initial dose of 400– 2000 micrograms IV; may be repeated at 2–3 minute intervals if the desired degree of counteraction and improvement in respiratory function is not obtained. (If no response after 10 mg then question the diagnosis of opioid induced toxicity.) OR give as an infusion: 4 mg in 20 mL (200 mcg/mL solution)

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