nalidixic acid.txt CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 600–900 mg every 6 hours PHARMACOKINETICS Molecular weight                           :232.2 %Protein binding                           :93–97 %Excreted unchanged in urine     : 11–33 (80–90% as inactive metabolites) Volume of distribution (L/kg)       :0.47–0.55 half-life – normal/ESRD (hrs)      :6–8/21 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Avoid. See ‘Other Information’ DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Unlikely to be dialysed. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Analgesics: increased risk of convulsions with NSAIDs Anticoagulants: anticoagulant effect of coumarins enhanced Ciclosporin: increased risk of nephrotoxicity Antimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant useTheophylline: possibly increased risk of convulsions ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– OTHER INFORMATION Avoid in severe renal impairment because the concentration in the urine is inadequate, and risk of monoglucuronide metabolite toxicity. Tags: post-by-auto-php Continue Reading Previous Previous post: iron sucrose .txtNext Next post: naratriptan.txt Related News sotalol hydrochloride.txt tazocin.txt