CLINICAL USE
Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)
DOSE IN NORMAL RENAL FUNCTION
200–600 mcg daily(Doses >400 mcg should be in 2 divided doses)
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–60 Dose as in normal renal function 10–30 Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
In moderately impaired renal function (GFR=30–60 mL/min) AUC is increased by 85% and clearance decreased by 52%; therefore, monitor patient closely .Anecdotal evidence suggests that moxonidine can be used safely at standard doses in patients with all degrees of renal impairment
One paper suggests that moxonidine can be used in patients with severe renal failure, at a dose of 300 mcg daily.