Moxifloxacin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

400 mg once daily

PHARMACOKINETICS

Molecular weight :437.9 (as hydrochloride)

%Protein binding :30–50

%Excreted unchanged in urine : 19

Volume of distribution (L/kg) :2

half-life – normal/ESRD (hrs) :12/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

30–50 Dose as in normal renal function10–30 Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Analgesics: increased risk of convulsions with NSAIDs

Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone, disopyramide and procainamide – avoid concomitant use

Antibacterials: increased risk of ventricular arrhythmias with parenteral erythromycin – avoid concomitant use

Anticoagulants: anticoagulant effect enhanced

Antidepressants: increased risk of ventricular arrhythmias with tricyclics – avoid concomitant useAntihistamines: increased risk of ventricular arrhythmias with mizolastine – avoid concomitant use

Antimalarials: increased risk of ventricular arrhythmias with chloroquine, hydroxychloroquine, mefloquine or quinine – avoid concomitant use; avoid concomitant use with artemether with lumefantrine

Antipsychotics: increased risk of ventricular arrhythmias with haloperidol, phenothiazines, pimozide or sertindole – avoid concomitant use

Beta-blockers: increased risk of ventricular arrhythmias with sotalol – avoid concomitant use

Ciclosporin: some reports of increased nephrotoxicity

Pentamidine: increased risk of ventricular arrhythmias – avoid concomitant useTheophylline: possibly increased risk of convulsions

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

Do not take milk, iron preparations, indigestion remedies or phosphate binders at the same time as moxifloxacin

OTHER INFORMATION

Oral bioavailability is 90% .

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