movicol.txt

CLINICAL USE

Laxative

DOSE IN NORMAL RENAL FUNCTION

1–3 sachets daily in divided doses in 125 mL of waterMaintenance: 1–2 sachets daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :3350

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not absorbed

%Excreted unchanged in urine &nbsp &nbsp : Not absorbed

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :Not absorbed

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :Not absorbed

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Not dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

Movicol contains polyethylene glycol, sodium chloride, sodium bicarbonate and potassium chlorideElectrolyte content of a sachet when made up with 125 mL water is:Sodium 65 mmol/L —Chloride 53 mmol/L —Potassium 5.4 mmol/L —Bicarbonate 17 mmol/L —Sachets are formulated to ensure that there is virtually no net gain or loss of sodium, potassium or waterMovicol (active ingredient is the osmotic laxative polyethylene glycol).

Tags: post-by-auto-php