CLINICAL USE

Prophylaxis of asthma

DOSE IN NORMAL RENAL FUNCTION

10 mg at night

PHARMACOKINETICS

  • Molecular weight                           :608.2 (as sodium salt)
  • %Protein binding                           :>99
  • %Excreted unchanged in urine     : <0.2
  • Volume of distribution (L/kg)       :8–11 litres
  • half-life – normal/ESRD (hrs)      :2.7–5.5

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Metabolites have minimal therapeutic activity.

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