CLINICAL USE

Excessive daytime drowsiness associated with narcolepsy, obstructive sleep apnoea and chronic shift work

DOSE IN NORMAL RENAL FUNCTION

200–400 mg daily in 1 or 2 divided dosesChronic shift work disorder: 200 mg taken 1 hour before the start of the shift

PHARMACOKINETICS

  • Molecular weight                           :273.4
  • %Protein binding                           :60
  • %Excreted unchanged in urine     :
  • <10           :
  • Volume of distribution (L/kg)       :0.9
  • half-life – normal/ESRD (hrs)      :15/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Start at 50% normal dose and increase according to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
  • HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
  • HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Ciclosporin: reduced ciclosporin concentration
  • Oestrogens: metabolism accelerated (reduced contraceptive effect)

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Major metabolite is not pharmacologically activeRecommended that modafinil not be used in patients with left ventricular hypertrophy or ischaemic ECG changes.

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