Minocycline.txt

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

100 mg twice dailyAcne: 100 mg daily in 1 or 2 divided doses

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :457.5

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :75

%Excreted unchanged in urine &nbsp &nbsp : 5–10

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :1–1.5

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :11–26/12–18

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione

Oestrogens: possibly reduced contraceptive effect of oestrogens (risk probably small)

Retinoids: possibly increased risk of benign intracranial hypertension – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as minocycline.

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