metoclopramide hydrochloride.txt

CLINICAL USE

Nausea and vomiting

DOSE IN NORMAL RENAL FUNCTION

10 mg 3 times a day. Use in patients under 20 years should be restricted

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :354.3

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :13–22

%Excreted unchanged in urine &nbsp &nbsp : 20–30

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :3.5

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :4–6/15

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Ciclosporin: increased ciclosporin blood levels

ADMINISTRATION

Reconstition

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Route

Oral, IV, IM

Rate of Administration

1–2 minutes

Comments

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OTHER INFORMATION

Increased risk of extrapyramidal reactions in severe renal impairmentCan be used for hiccups at a dose of 10 mg 3 times a day

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