CLINICAL USE

Nausea and vomiting

DOSE IN NORMAL RENAL FUNCTION

10 mg 3 times a day. Use in patients under 20 years should be restricted

PHARMACOKINETICS

  • Molecular weight                           :354.3
  • %Protein binding                           :13–22
  • %Excreted unchanged in urine     : 20–30
  • Volume of distribution (L/kg)       :3.5
  • half-life – normal/ESRD (hrs)      :4–6/15

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Dialysed. Dose as in normal renal function
  • HDF/high flux   :Dialysed. Dose as in normal renal function
  • CAV/VVHD      :Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Ciclosporin: increased ciclosporin blood levels

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral, IV, IM

    Rate of Administration

    1–2 minutes

    Comments

    –

    OTHER INFORMATION

    Increased risk of extrapyramidal reactions in severe renal impairmentCan be used for hiccups at a dose of 10 mg 3 times a day

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