20 to 50     : 500 mg – 2 g every 12 hours
10 to 20     : 500 mg – 1 g every 12 hours or 500 mg every 8 hours
<10           : 500 mg – 1 g every 24 hours
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Dialysed. Dose as in GFR
<10           : mL/min
HD                     :Dialysed. Dose as in GFR
<10           : mL/min or 1–2 g post dialysis2
HDF/high flux   :Dialysed. Dose as in GFR
<10           : mL/min
CAV/VVHD      :Dialysed. 0.5–1 g every 8 hours2,3 or 1 g every 12 hours1 CVVhdF1 g every 12 hours3
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsProbenecid: avoid concomitant use
ADMINISTRATION
Reconstition
Add 5 mL water for injection to each 250 mg of meropenem
Route
IV
Rate of Administration
Bolus: 5 minutes IV Infusion: 15–30 minutes
Comments
Further dilute in 50–200 mL sodium chloride 0.9%, glucose 5% or glucose 10% if for infusionStable for 24 hours once reconstituted Minimum volume 1 g in 10 mL. (UK Critical Care Group, Minimum Infusion Volumes for fluid restricted critically ill patients, 3 rd Edition, 2006)
OTHER INFORMATION
Metabolite is inactive and renally excreted Each 1 g vial contains 3.9 mmol of sodium Has less potential to induce seizures than imipenemHas been used intraperitoneally for peritoneal dialysis Pseudomonas peritonitis at concentration of 100 mg/L50% is removed by CVVHF, 13–53% by CVVHDF, 50% by intermittent
HD                     :.2Differences in renal replacement doses are due to the different flow rates used in the studies