mebendazole

CLINICAL USE

Treatment of threadworm, roundworm, whipworm, and hookworm infections

DOSE IN NORMAL RENAL FUNCTION

Threadworm: 100 mg as a single dose; if re- infection occurs repeat after 2–3 weeksWhipworm, roundworm, hookworm: 100 mg twice daily for 3 daysEchinococcosis: 40–50 mg/kg daily for at least 3–6 months

PHARMACOKINETICS

Molecular weight :295.3

%Protein binding :95

%Excreted unchanged in urine : 2

Volume of distribution (L/kg) :1–1.2

half-life – normal/ESRD (hrs) :0.93/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs
Cimetidine: possibly inhibits metabolism of mebendazole
Phenytoin, carbamazepine and phenobarbital: lower mebendazole concentrations, only relevant when being used in high doses for echinococcosis

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Contraindicated in pregnancy Undergoes first pass metabolism Poorly absorbed from the gastrointestinal tract (5–10%).

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