DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR <10 mL/min
HD                     :Not dialysed. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione
Oestrogens: possibly reduce contraceptive effects of oestrogens (risk probably small)
Retinoids: possible increased risk of benign intracranial hypertension – avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as lymecycline
OTHER INFORMATION
Lymecycline is a tetracycline derivative 408 mg lymecycline ≡ 300 mg tetracyclineNot recommended in severe renal impairment as lymecycline is mainly excreted by the kidneys.