CLINICAL USE

Antibacterial agent:Also used for treatment of acne

DOSE IN NORMAL RENAL FUNCTION

408 mg (1 capsule) twice daily, increasing to 3–4 capsules daily in severe infectionsAcne: 408 mg daily for at least 8 weeks

PHARMACOKINETICS

  • Molecular weight                           :602.6
  • %Protein binding                           :Approx 25–60
  • %Excreted unchanged in urine     : 25
  • Volume of distribution (L/kg)       :Approx 1.3–1.7
  • half-life – normal/ESRD (hrs)      :10/Increased

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Avoid. See ‘Other Information’

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in GFR <10 mL/min
  • HD                     :Not dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione
  • Oestrogens: possibly reduce contraceptive effects of oestrogens (risk probably small)
  • Retinoids: possible increased risk of benign intracranial hypertension – avoid concomitant use

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as lymecycline

    OTHER INFORMATION

    Lymecycline is a tetracycline derivative 408 mg lymecycline ≡ 300 mg tetracyclineNot recommended in severe renal impairment as lymecycline is mainly excreted by the kidneys.

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