Levofloxacin.txt Levofloxacin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 250–500 mg once or twice a day (varies depending on indication) PHARMACOKINETICS Molecular weight                           :361.4 %Protein binding                           :30–40 %Excreted unchanged in urine     : >85 Volume of distribution (L/kg)       :1.1–1.5 half-life – normal/ESRD (hrs)      :6–8/35 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Initial dose 250–500 mg then reduce dose by 50% 10 to 20     : Initial dose 250–500 mg then 125 mg 12–24 hourly <10           : Initial dose 250–500 mg then 125 mg 24–48 hourly DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :Not dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Not dialysed. Dose as in GFR <10 mL/minCAV/VVHD      :Not dialysed. Loading dose: 500 mg then 250 mg every 24 hours.1 IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Analgesics: possibly increased risk of convulsions with NSAIDs Anticoagulants: anticoagulant effect of coumarins and phenindione enhanced Antimalarials: manufacturer advises avoid concomitant use with artemether and lumefantrine Ciclosporin: half-life of ciclosporin increased by 33%; increased risk of nephrotoxicity Tacrolimus: may increase tacrolimus concentrationTheophylline: possibly increased risk of convulsions ADMINISTRATION Reconstition– Route Oral, IV Rate of Administration 30 minutes per 250 mg Comments OTHER INFORMATION Dose and frequency depend on indication Tags: post-by-auto-php Continue Reading Previous Previous post: Lepirudin.txtNext Next post: METATARSALGIA.txt Related News sotalol hydrochloride.txt tazocin.txt