Lenalidomide
CLINICAL USE
Treatment of multiple myeloma in combination with dexamethasone
DOSE IN NORMAL RENAL FUNCTION
25 mg daily on days 1–21 of a 28 day cycle; reduce dose if patient has neutropenia or thrombocytopenia; see data sheet
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–50 10 mg daily, increasing to 15 mg after 2 cycles if patient is not responding<30 15 mg every 48 hours
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsCardiac glycosides: possibly increases concentration of digoxin
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
May cause acute renal failure – monitor renal function during treatment. Patients with renal impairment are more likely to develop side effects