Leflunomide
CLINICAL USE
Disease modifying agent:Active rheumatoid arthritis Psoriatic arthritis
DOSE IN NORMAL RENAL FUNCTION
Rheumatoid arthritis: 100 mg daily for 3 days then
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsHepatotoxic or haemotoxic drugs: increased risk of toxicityLipid-lowering agents: effect significantly reduced by colestyramineLive vaccines: avoid concomitant use
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
Administer with food