Lanthanum carbonate
CLINICAL USE
Phosphate binder in patients with CKD 5
DOSE IN NORMAL RENAL FUNCTION
Usually 750 mg – 1.5 g 3 times a day with meals
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
Must be chewed WITH food; do not take before meals
OTHER INFORMATION
Following ingestion, lanthanum carbonate is converted in the GI tract to the insoluble lanthanum phosphate, which is not readily absorbed into the blood