Klean-Prep

CLINICAL USE

Colonic lavage prior to diagnostic examination or surgical procedures requiring a clean colon

DOSE IN NORMAL RENAL FUNCTION

4 sachets, each reconstituted in 1 litre of water, at a rate of 250 mL every 10–15 minutes

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :3350 (Macrogol)

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :N/A

%Excreted unchanged in urine &nbsp &nbsp : N/A

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :N/A

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :N/A

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not absorbed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not absorbed. Dose as in normal renal function

HDF/high flux &nbsp :Not absorbed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not absorbed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

Each sachet in 1 litre of water

Route

Oral

Rate of Administration

250 mL every 15–30 minutes If given via NG tube, rate is 20–30 mL/ minute

Comments

Klean-Prep is formulated to be hyper- osmotic and draw water into the bowel. None is absorbed systemically

OTHER INFORMATION

Each sachet of Klean-Prep contains:Polyethylene glycol 3350 – 59.0 g —Anhydrous sodium sulphate – 5.685 g —Sodium bicarbonate – 1.685 g —Sodium chloride – 1.465 g —Potassium chloride – 0.7425 g —The electrolyte content of 1 sachet when made up in 1 litre of water is:Sodium – 125 mmol —Sulphate – 40 mmol —Chloride – 35 mmol —Bicarbonate – 20 mmol —Potassium – 10 mmol

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