Anti-arrhythmics: increased risk of ventricular arrhythmias with disopyramide – avoid concomitant use
Antibacterials: metabolism increased by rifampicin; may reduce rifampicin concentration; concentration possibly reduced by isoniazid; avoid concomitant use with telithromycin in severe renal and hepatic impairment
Anticoagulants: anticoagulant effect of coumarins enhanced
Antidepressants: avoid concomitant use with reboxetine; ketoconazole increases concentration of mirtazepine
Anti-epileptics: concentration of ketoconazole reduced by phenytoin; concentration of carbamazepine possibly increasedAntihistamines: concentration of loratidine possibly increased; avoid concomitant use with mizolastine
Antimalarials: manufacturer advises avoid artemether and lumefantrine with ketoconazole
Antipsychotics: increased risk of ventricular arrhythmias with pimozide – avoid concomitant use; possibly increased concentration of quetiapine – reduce quetiapine dose; increased risk of ventricular arrhythmias with sertindole – avoid concomitant use; inhibits aripiprazole metabolism – reduce aripiprazole dose
Antivirals: concentration of both drugs increased with darunavir; inhibits metabolism of indinavir; concentration reduced by nevirapine – avoid concomitant use; ketoconazole and ritonavir can increase concentration of each other; concentration of saquinavir increased; concentration increased by amprenavirAnxiolytics and hypnotics: concentration of alprazolam and midazolam increased (risk of prolonged sedation)
Calcium-channel blockers: increased concentration of felodipine; avoid with lercanidipine and nisoldipine; possibly inhibits metabolism of dihydropyridines
Ergot alkaloids: increased risk of ergotism with ergotamine and methysergide – avoid concomitant use5HT 1 agonists: increased concentration of eletriptan – avoid concomitant use; increased almotriptan concentration (increased toxicity).KEToConAZoLE 407Ivabradine: concentration of ivabradine increased – avoid concomitant useLanthanum: reduces absorption of ketoconazole – give at least 2 hours apartSirolimus: concentration increased by ketoconazole – avoid concomitant useStatins: possibly increased risk of myopathy with atorvastatin and simvastatin – avoid concomitant use with simvastatin
Tacrolimus: increased tacrolimus concentrationTheophylline; possibly increased concentration of theophylline
Vardenafil: increased concentration of vardenafil, avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral, topical
Rate of Administration
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Comments
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OTHER INFORMATION
Monitor LFTs especially if on long-term treatment.