Ispaghula husk

CLINICAL USE

Bulk-forming laxative

DOSE IN NORMAL RENAL FUNCTION

Fibrelief: 1–6 sachets daily in water in 1–3 divided dosesFybogel: One sachet (3.5 g) in water twice dailyIsogel: 2 teaspoonfuls in water 1–2 times daily (constipation), 3 times daily (diarrhoea)Regulan: 1 sachet in water 1–3 times daily

PHARMACOKINETICS

Molecular weight :–

%Protein binding :0

%Excreted unchanged in urine : 0

Volume of distribution (L/kg) :Not absorbed

half-life – normal/ESRD (hrs) :Not absorbed

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Fybogel and regulan should be stirred into 150 mL water and taken as quickly as possible, preferably after mealsAdditional fluid intake should be maintained

OTHER INFORMATION

Fybogel is low in sodium and potassium, containing approximately 0.4 mmol sodium and 0.7 mmol potassium per sachet. It is sugar and gluten free and contains aspartame (contributes to the phenylalanine intake and may affect control of phenylketonuria)Orange and lemon/lime flavours of regulan contain: 3.4 g ispaghula husk BP, 0.23 mmol sodium, <1 mmol potassium per sachet and are gluten and sugar free. They also contain aspartameFibrelief contains aspartame Fluid restrictions in dialysis patients can render these treatments inappropriate

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