iron sucrose
CLINICAL USE
Prophylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated) Treatment of iron deficiency during epoetin therapy especially if serum ferritin is very low (<50 nanograms/mL)
DOSE IN NORMAL RENAL FUNCTION
According to local protocol.
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsDimercaprol: avoid concomitant use Do not administer with oral iron
ADMINISTRATION
Reconstition
–
Route
IV
Rate of Administration
Bolus: 1 mL/minute Infusion: in sodium chloride 0.9% at a concentration of 1 mg/mL over 20–30 minutes per 100 mg
Comments
A test dose is required before administrationDoses can be administered via the venous limb of the dialysis machineStable for 24 hours at room temperature
OTHER INFORMATION
Some regimes are: 50–300 mg weekly —100 mg once or twice monthly —20–40 mg with each dialysis —Oral iron can be restarted 5 days after completion of the course of IV iron