hyoscine hydrobromide

CLINICAL USE

Motion sickness Premedication Palliative care

DOSE IN NORMAL RENAL FUNCTION

Motion sickness: Oral: 300 mcg 30 minutes before start —of journey then 300 mcg every 6 hours if required; maximum 3 doses in 24 hoursTopical: 1 patch 5–6 hours before —journey, replace after 72 hoursPremedication (SC/IM): 200–600 mcg 30–60 minutes before anaesthesiaSC Infusions: Excessive secretions (patch can also be used for this indication): 0.6–2.4 mg over 24 hoursBowel colic: 20–60 mg over 24 hours

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :438.3

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :10

%Excreted unchanged in urine &nbsp &nbsp : 2 (1 – oral, 34 – transdermal)

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :No data

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :8

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

Oral, topical, SC, IM

Rate of Administration

–

Comments

–

OTHER INFORMATION

Only 2–8% of oral dose is absorbed

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