Griseofulvin

CLINICAL USE

Antifungal agent:Dermatophyte infections of the skin, scalp, hair and nails

DOSE IN NORMAL RENAL FUNCTION

500 mg daily, in divided doses or as a single dose, in severe infection dose may be doubled

PHARMACOKINETICS

Molecular weight :352.8

%Protein binding :84

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :1.2–1.41

half-life – normal/ESRD (hrs) :9–24/20

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: metabolism of coumarins accelerated (reduced anticoagulant effect)

Ciclosporin: griseofulvin possibly reduces ciclosporin concentration (two reports of such an interaction in literature)Oestrogens and progestogens: metabolism of oral contraceptives accelerated (reduced contraceptive effect)

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Use with extreme caution in patients with SLE.

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